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In some people, the pain extends to the right shoulder

Simultaneously, its GLP-1 receptor agonist activity stimulates insulin release, suppresses glucagon secretion, slows gastric emptying, and reduces appetite

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By engaging all three pathways simultaneously, retatrutide is designed to produce a more pronounced effect on body weight and metabolic health than single or dual agonists, though direct head-to-head comparative trials have not yet been conducted